DESCRIPTION
5.procaine, the hydrochloride of which is called novocain." "With its hydrochloride, it is a white crystalline or crystalline powder, odorless, slightly bitter in taste, followed by a sense of paralysis, and easily soluble in water." The duration of local anesthesia with procaine was about 1 hour, and the effect could be maintained for 1 to 2 hours if a trace amount of epinephrine was added to the solution. Its weak penetration into the skin and mucosa makes it unsuitable for topical anesthesia. "After absorption, it is mainly hydrolyzed to p-aminobenzoic acid and diethylaminoethanol by pseudocholinesterase in plasma." The former can compete against the antibacterial Chemicalbook effect of sulfonamides and weaken the efficacy of sulfonamides. The latter can enhance the effect of digitalis. Patients who have taken sufficient digitalis should use this medicine with caution. If procaine is combined with succinylcholine, both drugs are hydrolyzed by plasma pseudocholinesterase. In the case of intravenous infusion of a large amount of procaine, it is possible to reduce the hydrolysis and inactivation of succinylcholine by competition with hydrolase, and obviously strengthen and prolong its muscle relaxation, resulting in respiratory muscle paralysis. If a large amount of procaine is absorbed, it will produce excitatory effect on the central nervous system and then turn to inhibition, which is manifested as restlessness, convulsion, coma, respiratory paralysis, and allergic reaction in a few patients.-
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2022-12-20 16:13:26
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